Ruxolitinib API And Intermediates
Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
Ruxolitinib is a Janus kinase inhibitor that is used in the treatment of intermediate or high risk myelofibrosis and resistant forms of polycythemia vera and graft-vs-host disease. Ruxolitinib is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury and to cases of reactivation of hepatitis B in susceptible individuals.
Ruxolitinib cas 941678-49-5; INCB018424; Ruxolitinib (INCB018424); (R)-3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile; INCB-018424; INCB 018424; UNII-82S8X8XX8H;
Ruxolitinib cas 941678-49-5,Ruxolitinib cas 2075-45-8,Ruxolitinib cas 269410-08-4,Ruxolitinib cas 941685-26-3,Ruxolitinib cas 941685-27-4 Offering.
Ruxolitinib cas 941678-49-5,Ruxolitinib cas 2075-45-8,Ruxolitinib cas 269410-08-4,Ruxolitinib cas 941685-26-3,Ruxolitinib cas 941685-27-4 Â Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com
Description of Pet Flakes Recycling and Pelletizing Machine
Twin screw extruder recycling & pelletizing system are applied to the waste materials, which needs high processing performance of melting, volatilization, filtering etc., mainly works for the job of PET scraps recycling and re-pelletizing.
To slowing down IV reducing during PET flakes/scraps recycling, not only impurities, such as PVC content, moisture, etc., but also precise recycling system and reliable equipment configurations are necessary to put in the solution.
PET plastic pelletizing machine with international advanced recycling technology and combined with the actual application condition. This PET plastic pelletizing machine is design specializes for recycling the recycled washed plastic PET plastic flakes/scraps, such as Cola plastic bottle flakes/scraps, purified water bottle flakes/scraps, PET sheet flakes/scraps, PET drinking bottle flakes/scraps etc.
After processing techniques such as feeding, heating, melt, cooling, drying, cutting etc., the final products are PET plastic pellets/granules that can be to produce new PET plastic products.
Â
Features of Pet Flakes Recycling and Pelletizing Machine
The screw is made of high tool steel 38 CrMoALA or W6Mo5Cr4V2. Special screw combination Euro-style rectangle barrel, reflux refrigeration channel optimized and disposed, which makes temperature difference in D areas smaller.
Innovated design of heater-tightened style insures high efficiency of heat transfer and high longevity of heater.
The material is used high quality nitride steel, corrosion proof or antifriction with corresponding processed special designed two sets of vacuum.
New-style project of parallel three-axis driving makes the convex axis, convey Chain, decelerate and torque get together, which keep it compact, and the key bearings are imported soakage and spraying lubrication integrate smoothly technics, strengthening of tooth face, so they can ensure high torque, high precision and low noise
The selected material of drive components is dainty, including super intention alloy, cementiteing steel, cementiting and grinding.
Working Flow of Pet Flakes Recycling and Pelletizing Machine
Screw feeder → Parrallel Twin Screw Efficient extruder → Non-stop hydraulic screen filter changer → Water cooling → Strand cutting → Blower → Storage hopper → Electric control panel
1. Screw feeder: the first step of the pelletizing recycling machine, PET plastic flakes/scraps conveyed into the hopper through screw, the screw connect sensor to detect the material in hopper, once the flakes are full in hopper, the screw will stop; and once empty, the screw feeder will begin working.
2. Extruder: to plasticization and degassing, a specialized single screw extruder applied to melt the pre-compacted material. The plastic scraps will well melted, plasticized in the first stage extruder, and the plastic will be extrude by the second stage extruder. With double-zone vacuum degassing system, volatiles such as low molecular and moisture will be removed efficiency, especially suitable to heavy printed film and material with some water content.
3. Non-stop hydraulic screen filter changer: double stage filtering, fore filtering in the first extruder, and fine filtering in the second extruder, to reduce the frequency of filtering sieves changing. The requirements on the filter technology depend heavily on the quality of the input material as well as the planned use of granules.
4. Water cooling: made of 304 stainless steel, 4 meters length that fill with water, too cooling the melted plastic.
5. Cutting pelletizing: supplied with speed steel and hard alloy steel cutting blades for reliable performance. Compact structure allows less maintenance.
Pet Flakes Recycling and Pelletizing Machine Parameters
CAPACITY
(kg/h) POWER CONSUMPTION
(kw) WATER CONSUMPTION Â
LABOUR
HUMIDITY CONTENT
100-150
150
Keep water cool
1-2
<2%
250-300
200
Keep water cool
1-2
<2%
350-400
280
Keep water cool
1-2
<2%
450-500
360
Keep water cool
1-2
<2%
Pet Flakes Recycling and Pelletizing Machine Advantage:
Very low labor request.
Automatic constant temperature control.
CE certification, ISO9001 certification, SGS certification
Stable running, higher output and lower energy consumption.
Configuration based on client requirement and material, and give reasonable suggest.
We are professional 500-600kg/H Pet Waste Film Strands Pelletizing System for Extrusion Line manufacturer factory.
Any question please contact me
Mob: +86 13913190110Â (Whtap/ Vber/ Telgram/ Line / Wecha)
Â
Description of Pet Flakes Recycling and Pelletizing Machine
Twin screw extruder recycling & pelletizing system are applied to the waste materials, which needs high processing performance of melting, volatilization, filtering etc., mainly works for the job of PET scraps recycling and re-pelletizing.
To slowing down IV reducing during PET flakes/scraps recycling, not only impurities, such as PVC content, moisture, etc., but also precise recycling system and reliable equipment configurations are necessary to put in the solution.
PET plastic pelletizing machine with international advanced recycling technology and combined with the actual application condition. This PET plastic pelletizing machine is design specializes for recycling the recycled washed plastic PET plastic flakes/scraps, such as Cola plastic bottle flakes/scraps, purified water bottle flakes/scraps, PET sheet flakes/scraps, PET drinking bottle flakes/scraps etc.
After processing techniques such as feeding, heating, melt, cooling, drying, cutting etc., the final products are PET plastic pellets/granules that can be to produce new PET plastic products.
Â
Features of Pet Flakes Recycling and Pelletizing Machine
The screw is made of high tool steel 38 CrMoALA or W6Mo5Cr4V2. Special screw combination Euro-style rectangle barrel, reflux refrigeration channel optimized and disposed, which makes temperature difference in D areas smaller.
Innovated design of heater-tightened style insures high efficiency of heat transfer and high longevity of heater.
The material is used high quality nitride steel, corrosion proof or antifriction with corresponding processed special designed two sets of vacuum.
New-style project of parallel three-axis driving makes the convex axis, convey Chain, decelerate and torque get together, which keep it compact, and the key bearings are imported soakage and spraying lubrication integrate smoothly technics, strengthening of tooth face, so they can ensure high torque, high precision and low noise
The selected material of drive components is dainty, including super intention alloy, cementiteing steel, cementiting and grinding.
Working Flow of Pet Flakes Recycling and Pelletizing Machine
Screw feeder → Parrallel Twin Screw Efficient extruder → Non-stop hydraulic screen filter changer → Water cooling → Strand cutting → Blower → Storage hopper → Electric control panel
1. Screw feeder: the first step of the pelletizing recycling machine, PET plastic flakes/scraps conveyed into the hopper through screw, the screw connect sensor to detect the material in hopper, once the flakes are full in hopper, the screw will stop; and once empty, the screw feeder will begin working.
2. Extruder: to plasticization and degassing, a specialized single screw extruder applied to melt the pre-compacted material. The plastic scraps will well melted, plasticized in the first stage extruder, and the plastic will be extrude by the second stage extruder. With double-zone vacuum degassing system, volatiles such as low molecular and moisture will be removed efficiency, especially suitable to heavy printed film and material with some water content.
3. Non-stop hydraulic screen filter changer: double stage filtering, fore filtering in the first extruder, and fine filtering in the second extruder, to reduce the frequency of filtering sieves changing. The requirements on the filter technology depend heavily on the quality of the input material as well as the planned use of granules.
4. Water cooling: made of 304 stainless steel, 4 meters length that fill with water, too cooling the melted plastic.
5. Cutting pelletizing: supplied with speed steel and hard alloy steel cutting blades for reliable performance. Compact structure allows less maintenance.
Pet Flakes Recycling and Pelletizing Machine Parameters
CAPACITY
(kg/h) POWER CONSUMPTION
(kw) WATER CONSUMPTION Â
LABOUR
HUMIDITY CONTENT
100-150
150
Keep water cool
1-2
<2%
250-300
200
Keep water cool
1-2
<2%
350-400
280
Keep water cool
1-2
<2%
450-500
360
Keep water cool
1-2
<2%
Pet Flakes Recycling and Pelletizing Machine Advantage:
Very low labor request.
Automatic constant temperature control.
CE certification, ISO9001 certification, SGS certification
Stable running, higher output and lower energy consumption.
Configuration based on client requirement and material, and give reasonable suggest.
We are professional 500-600kg/H Pet Waste Film Strands Pelletizing System for Extrusion Line manufacturer factory.
Any question please contact me
Mob: +86 13913190110Â (Whtap/ Vber/ Telgram/ Line / Wecha)
Â
500-600kg/H Pet Waste Film Strands Pelletizing System for Extrusion Line
Model NO.: YRF-pelletzing system
Customized: Customized
Certification: CE, ISO9001:2008, SGS
Condition: New
Belong: Plastic Granulator
Color: Green (Customizable)
Motor: Siemens
Contactor: Schneider
Inveter: ABB
Machine Material: 38 Crmoal
Object: Washed Recycled Pet Plastic Flakes
Warranty: >12 Months
Type: Pet Flakes Recycling and Pelletizing Machine
Name: Pet Flakes Recycling and Pelletizing Machine
Trademark: YUREFON
Transport Package: Film Packing, Seaworthy Packing
Specification: 100kg/h-600kg/h
Origin: Zhangjiagang, Suzhou, China
HS Code: 8477800000
Model NO.: YRF-pelletzing system
Customized: Customized
Certification: CE, ISO9001:2008, SGS
Condition: New
Belong: Plastic Granulator
Color: Green (Customizable)
Motor: Siemens
Contactor: Schneider
Inveter: ABB
Machine Material: 38 Crmoal
Object: Washed Recycled Pet Plastic Flakes
Warranty: >12 Months
Type: Pet Flakes Recycling and Pelletizing Machine
Name: Pet Flakes Recycling and Pelletizing Machine
Trademark: YUREFON
Transport Package: Film Packing, Seaworthy Packing
Specification: 100kg/h-600kg/h
Origin: Zhangjiagang, Suzhou, China
HS Code: 8477800000
500-600kg/H Pet Waste Film Strands Pelletizing System for Extrusion Line
500-600kg/H Pet Waste Film Strands Pelletizing System for Extrusion Line